Florence (SC) staycation hotels

North America · United States

Your Florence (SC) Staycation

Hand-picked hotels in Florence (SC) — ranked by real guest scores, with live Agoda rates and one-tap booking. From boutique hideaways to luxury icons, every stay is curated by Staycation.

43
Curated stays
7.9/ 10
Average guest score

43 properties · curated by Staycation

Hampton Inn & Suites by Hilton Florence CenterHotel
Florence (SC), United States
Hampton Inn & Suites by Hilton Florence Center
★★★
9.0Exceptional
For your dates
$222 USD
Holiday Inn Express & Suites Florence By IHGHotel
Florence (SC), United States
Holiday Inn Express & Suites Florence By IHG
★★★
8.6Excellent
For your dates
$188 USD
Homewood Suites by Hilton FlorenceHotel
Florence (SC), United States
Homewood Suites by Hilton Florence
★★★
9.4Exceptional
For your dates
$185 USD
Staybridge Suites Florence - Civic Center By IHGHotel
Florence (SC), United States
Staybridge Suites Florence - Civic Center By IHG
★★★
9.7Exceptional
For your dates
$170 USD
Home2 Suites by Hilton FlorenceHotel
Florence (SC), United States
Home2 Suites by Hilton Florence
★★★
9.5Exceptional
For your dates
$166 USD
Holiday Inn Express & Suites Florence I-95 & I-20 Civic CtrHotel
Florence (SC), United States
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr
★★★
9.3Exceptional
For your dates
$161 USD
Fairfield by Marriott Inn & Suites Florence I-20Hotel
Florence (SC), United States
Fairfield by Marriott Inn & Suites Florence I-20
★★★
8.7Excellent
For your dates
$161 USD
Comfort Inn & Suites Florence Center AreaHotel
Florence (SC), United States
Comfort Inn & Suites Florence Center Area
★★★
9.0Exceptional
For your dates
$155 USD
Hotel Florence, Tapestry Collection by HiltonHotel
Florence (SC), United States
Hotel Florence, Tapestry Collection by Hilton
★★★★
9.4Exceptional
For your dates
$149 USD
Hyatt Place Florence DowntownHotel
Florence (SC), United States
Hyatt Place Florence Downtown
★★★
9.3Exceptional
For your dates
$148 USD
TownePlace Suites by Marriott FlorenceHotel
Florence (SC), United States
TownePlace Suites by Marriott Florence
★★★★
4.4Good
For your dates
$148 USD
Residence Inn by Marriott FlorenceHotel
Florence (SC), United States
Residence Inn by Marriott Florence
★★★
9.4Exceptional
For your dates
$144 USD
Aloft by Marriott FlorenceHotel
Florence (SC), United States
Aloft by Marriott Florence
★★★
8.5Excellent
For your dates
$143 USD
SpringHill Suites by Marriott FlorenceHotel
Florence (SC), United States
SpringHill Suites by Marriott Florence
★★★
8.9Excellent
For your dates
$142 USD
Comfort Suites Florence I-95Hotel
Florence (SC), United States
Comfort Suites Florence I-95
★★★
8.2Excellent
For your dates
$132 USD
Courtyard by Marriott FlorenceHotel
Florence (SC), United States
Courtyard by Marriott Florence
★★★
7.1Very Good
For your dates
$132 USD
Hilton Garden Inn FlorenceHotel
Florence (SC), United States
Hilton Garden Inn Florence
★★★
8.5Excellent
For your dates
$131 USD
Hampton Inn & Suites Florence-North-I-95Hotel
Florence (SC), United States
Hampton Inn & Suites Florence-North-I-95
★★★
8.9Excellent
For your dates
$128 USD
Tru by Hilton Florence I-95Hotel
Florence (SC), United States
Tru by Hilton Florence I-95
★★★
7.2Very Good
For your dates
$123 USD
Park Inn by Radisson Florence, SCHotel
Florence (SC), United States
Park Inn by Radisson Florence, SC
★★★
8.6Excellent
For your dates
$112 USD
Best Western InnHotel
Florence (SC), United States
Best Western Inn
7.6Very Good
For your dates
$109 USD
Quality Inn & Suites Florence Civic CenterHotel
Florence (SC), United States
Quality Inn & Suites Florence Civic Center
★★★
8.4Excellent
For your dates
$99 USD
Spark by Hilton Florence North I-95, SCHotel
Florence (SC), United States
Spark by Hilton Florence North I-95, SC
★★★
7.2Very Good
For your dates
$98 USD
La Quinta Inn & Suites by Wyndham FlorenceHotel
Florence (SC), United States
La Quinta Inn & Suites by Wyndham Florence
★★★
8.3Excellent
For your dates
$87 USD
Sleep Inn Florence NorthHotel
Florence (SC), United States
Sleep Inn Florence North
★★★
8.2Excellent
For your dates
$81 USD
MainStay Suites Florence - DarlingtonHotel
Florence (SC), United States
MainStay Suites Florence - Darlington
★★★
5.9Good
For your dates
$80 USD
Affordable Suites FlorenceHotel
Florence (SC), United States
Affordable Suites Florence
★★
10.0Exceptional
For your dates
$77 USD
Days Inn by Wyndham Florence Near Civic CenterHotel
Florence (SC), United States
Days Inn by Wyndham Florence Near Civic Center
★★★
8.3Excellent
For your dates
$72 USD
Howard Johnson by Wyndham FlorenceHotel
Florence (SC), United States
Howard Johnson by Wyndham Florence
★★
8.7Excellent
For your dates
$70 USD
Red Roof Inn Florence - Civic CenterHotel
Florence (SC), United States
Red Roof Inn Florence - Civic Center
★★
6.8Good
For your dates
$66 USD
Microtel Inn & Suites by Wyndham FlorenceHotel
Florence (SC), United States
Microtel Inn & Suites by Wyndham Florence
★★
7.2Very Good
For your dates
$65 USD
Suburban Studios Florence I-95Hotel
Florence (SC), United States
Suburban Studios Florence I-95
★★
6.1Good
For your dates
$65 USD
Motel 6 Florence, SCHotel
Florence (SC), United States
Motel 6 Florence, SC
★★
4.8Good
For your dates
$65 USD
Super 8 By Wyndham FlorenceHotel
Florence (SC), United States
Super 8 By Wyndham Florence
★★
7.6Very Good
For your dates
$64 USD
Rodeway Inn Florence DowntownHotel
Florence (SC), United States
Rodeway Inn Florence Downtown
★★
0.0Good
For your dates
$63 USD
Days Inn by Wyndham Florence/I-95 NorthHotel
Florence (SC), United States
Days Inn by Wyndham Florence/I-95 North
★★
7.3Very Good
For your dates
$60 USD
Super 8 by Wyndham Florence SC I-95 North / Hwy 76Hotel
Florence (SC), United States
Super 8 by Wyndham Florence SC I-95 North / Hwy 76
★★
6.0Good
For your dates
$59 USD
Econo Lodge Florence - DarlingtonHotel
Florence (SC), United States
Econo Lodge Florence - Darlington
★★
6.4Good
For your dates
$58 USD
Clarion Inn & Suites Florence - DarlingtonHotel
Florence (SC), United States
Clarion Inn & Suites Florence - Darlington
★★★
5.7Good
For your dates
$58 USD
Studio 6 Florence, SCHotel
Florence (SC), United States
Studio 6 Florence, SC
★★
6.8Good
For your dates
$56 USD
Florence Inn and SuitesHotel
Florence (SC), United States
Florence Inn and Suites
★★★
8.3Excellent
For your dates
$50 USD
Hilton Garden Inn Florence North I 95Hotel
Florence (SC), United States
Hilton Garden Inn Florence North I 95
★★★
0.0Good
AVID HOTELS Florence North by IHGHotel
Florence (SC), United States
AVID HOTELS Florence North by IHG
0.0Good

The Best Florence (SC) Staycation Hotels

Whether you’re planning a weekend staycation in Florence (SC) or a longer escape acrossUnited States, Staycation curates the finest places to stay — from boutique hideaways and heritage hotels to iconic luxury properties. Every Florence (SC) staycation hotel is ranked by real guest scores, so you can book with confidence.

Rates are powered by Agoda, with live availability and competitive pricing. Pick your dates above to see tonight’s best Florence (SC) staycation deals, or explore other destinations in North America.